Evaluasi Penggunaan Antibiotik pada Pasien Tifoid Rawat Inap di Rumah Sakit Ulin Banjarmasin dengan Metode Gyssens dan ATC/DDD

Antung Sinta Dewi; Saftia Aryzki; Kunti Nastiti

doi:10.55681/sentri.v4i12.5021

Authors

Antung Sinta Dewi Universitas Sari Mulia
Saftia Aryzki Universitas Sari Mulia
Kunti Nastiti Universitas Sari Mulia

DOI:

https://doi.org/10.55681/sentri.v4i12.5021

Keywords:

Antibiotics, ATC/DDD Gyssens, Typhoid

Abstract

Typhoid is a gastrointestinal infection caused by Salmonella typhi. The disease is transmitted through contaminated food and beverages and can spread from infected individuals. Symptoms typically appear 1–3 weeks after exposure and include high fever, malaise, headache, constipation, diarrhea, and enlargement of the liver and spleen. At a hospital in South Kalimantan in 2022, 80% on cases of typhoid treatment can use antibiotics. One study showed resistance of salmonella typhi to antibiotics such as ampicillin, amoxicillin, and chloramphenicol. To evaluate the use of antibiotics both quantitatively using the ATC/DDD methods and qualitatively using the Gyssens methods for hospitalized typhoid patients at Ulin Regional Hospital, Banjarmasin, in 2024. This study uses quantitative data with the Gyssens method and qualitative data with the ATC/DDD method in typhoid patients. The research was conducted over one month, from June to July 2025, at Ulin Hospital Banjarmasin the Sample 7. Quantitative evaluation showed a total of 488,93 DDD/100 patient-days with DU 90% analysis. Qualitative evaluation using the Gyssens method indicated that 71.42% of antibiotic use was rational. Ampicillin was categorized as IVa (1 patient), a combination of Metronidazole, Ceftazidime, and Cefixime was categorized as IVa (1 patient), and five patients receiving combination therapy fell under category 0 (rational). The majority of antibiotic use was considered rational. Antibiotic use in hospitalized typhoid patients at Ulin General Hospital Banjarmasin in 2024 was largely rational.

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References

I. G. A. N. D. Sukmawati, M. A. Jaya, and D. A. Swastini, “Evaluasi penggunaan antibiotik pada pasien tifoid rawat inap,” Jurnal Farmasi Udayana, 2020, doi: 10.24843/jfu.2020.v09.i01.p06.

M. A. Kurnianto and F. Syahbanu, “Resistensi antibiotik pada rantai pasok pangan,” Agrointek, 2023, doi: 10.21107/agrointek.v17i3.14771.

M. Sabir, R. Dwiyanti, and A. N. Asrinawaty, “Resistensi antibiotik terhadap bakteri Salmonella typhi: Literature Review,” Promotif: Jurnal Kesehatan Masyarakat, 2023.

S. Hanifah, I. Melyani, and L. Madalena, “Evaluasi Penggunaan Antibiotik dengan Metode ATC/DDD dan DU90% pada Pasien Rawat Inap KSM Penyakit Dalam,” Farmaka, 2022.

S. D. Khoiriyah, R. Ratnawati, and E. Halimah, “Evaluasi Penggunaan Antibiotik Menggunakan Metode ATC/DDD dan DU90% di Rawat Jalan Poli Penyakit Dalam RS Al-Islam Bandung,” Jurnal Kefarmasian Akfarindo, 2020.

N. Dewi and D. Juliadi, “Faktor Penyebab Perilaku Penjualan dan Pembelian Antibiotik Tanpa Resep Dokter,” Jurnal Farmasi & Sains Indonesia, vol. 4, no. 2, pp. 19–25, Oct. 2021, doi: 10.52216/jfsi.vol4no2p19-25.

S. A. Putri and D. M. Oktavilantika, “Evaluasi Rasionalitas Penggunaan Antibiotik Pada Pasien Demam Tifoid di Instalasi Rawat Inap RS ‘X’ Indramayu Dengan Metode Gyssens,” Jurnal Farmasi dan Farmakoinformatika, 2023.

P. Taher, P. Oktanauli, and S. R. Anggraini, “Rasionalitas Penggunaan Antibiotika Pada Pasien Poli Gigi Salah Satu Rumah Sakit Pendidikan di Jakarta,” Jurnal Ilmiah dan Teknologi Kedokteran Gigi, 2020.

E. Hartoyo, A. Yunanto, and L. Budiarti, “Uji sensitivitas Salmonella typhi terhadap berbagai antibiotik di bagian anak RSUD Ulin Banjarmasin,” Sari Pediatri, 2016.

S. Hanifah, I. Melyani, and L. Madalena, “EVALUASI PENGGUNAAN ANTIBIOTIK DENGAN METODE ATC/DDD DAN DU90% PADA PASIEN RAWAT INAP KELOMPOK STAFF MEDIK PENYAKIT DALAM DI SALAH SATU RUMAH SAKIT SWASTA DI KOTA BANDUNG.” [Online]. Available: https://www.whocc.no/atc_ddd_index/.

F. Nabila Putri, “Evaluasi Penggunaan Antibiotik pada Pasien Tifoid Rawat Inap dengan Metode Gyssens di RSUD dr. Soekardjo Tasikmalaya,” 2024.

J. F. Tobing, “Demam Tifoid,” IKRA-ITH Humaniora, 2024, doi: 10.37817/ikraith-humaniora.v8i2.

S. D. Khoiriyah, R. Ratnawati, and E. Halimah, “EVALUASI PENGGUNAAN ANTIBIOTIK DENGAN METODE ATC/DDD DAN DU90% DI RAWAT JALAN POLI PENYAKIT DALAM RUMAH SAKIT AL-ISLAM BANDUNG EVALUATION OF THE USE OF ANTIBIOTICS WITH ATC / DDD AND DU90% METHODS AT THE POLYCLINIC INTERNIST AT AL-ISLAM HOSPITAL IN BANDUNG.”